Induction of Apoptosis by Cynaropicrin in Human Colon Cancer Cell Line HCT-116 through the Mitochondria-mediated Apoptotic Pathway

Background Colon cancer continues to be the third most commonly occurring around globe with both lifestyle-related risk factors and genetic dispositions. Owing increased incidence of disease, there is a need find new treatment options which are easily accessible less toxic cells. Cynaropicrin, sesquiterpene extract from artichoke plant exhibits varied properties such as anti-inflammatory, anti-cancer, anti-oxidant among others. In current investigation, anti-cancer potential cynaropicrin was observed against colon in HCT-116 cell lines. Materials Methods The drug exhibited considerable decrease proliferation. Also analyzed reactive oxygen species (ROS) generation apoptosis induction by on line. AO/EtBr staining confirmed apoptotic through chromatin condensation fluorescence microscopic examination followed DAPI treated cells showed nuclear disintegration. Results Furthermore, it that elevated levels ROS modified mitochondrial membrane permeability study also evaluated proteins expression inflammatory cytokines concerning untreated control Conclusion It has been can lead line via mitochondria-mediated pathway if further evaluated, turn out potent for effective management cancer.